The Nature Neuroscience Podcast Neuropod has an interview with Leslie Griffith, who has been studying sleep in flies. In the study, researchers alttered the excitability of ventral lateran neurons (LNvs) with GABA, the chief inhibitory transmitter. When it was time to wake the flies up, the LNvs are believed to release a neuropeptide known as PDF.
Griffith believes that this research may help in sleep disorders in humans. Most medication for sleep disorders supress GABA throughout the brain. Griffith believes that it would be advantageous to target sleep medication specifically to the sleep circuit.
Link to Neuropod.
Link to Story on ScienceDaily.